January 1, 1998Clinical Science
Rate of Gastric Emptying is a Determinant of Postprandial Hypotension in Non-Insulin-Dependent Diabetes Mellitus
Why the study?
Does the rate of gastric emptying determine the magnitude of postprandial hypotension after glucose ingestion in patients with NIDDM?
Population
35 subjects: 16 patients with recently diagnosed non-insulin-dependent diabetes mellitus, 10 'young' normal…
Comparison
Ingestion of 75 g of glucose in 350 ml of water… vs Normal subjects (young and older cohorts)
Design
Cross-sectional
Follow-up
180 minutes
Authors
Discussion
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Implication
Greater postprandial BP fall associated with faster gastric emptying in NIDDM; leaves open whether modulating emptying alters risk, pending trials.
Structured PICO
Does the rate of gastric emptying determine the magnitude of postprandial hypotension after glucose ingestion in patients with NIDDM?
P
Population
35 subjects: 16 patients with recently diagnosed non-insulin-dependent diabetes mellitus (NIDDM) (median age 57), 10 'young' normal subjects (median age 23), and 9 'older' normal subjects (median age 48).
I
Intervention
Ingestion of 75 g of glucose in 350 ml of water after an overnight fast
C
Comparator
Normal subjects (young and older cohorts)
O
Outcome
Relationship between changes in blood pressure and the rate of gastric emptying after glucose ingestionsurrogate
In patients with recently diagnosed NIDDM, the postprandial fall in blood pressure is greater than in normal subjects and is significantly related to the rate of gastric emptying.
Cite This Study
Jones et al. (1998) studied this question.