Why the study?
Is serum estradiol concentration associated with mortality in men with chronic heart failure and reduced LVEF?
Population
501 men with chronic heart failure and reduced LVEF, mean age 58 years, NYHA classes 1-4, recruited at 2…
Comparison
Serum estradiol concentration quintiles vs Middle quintile of serum estradiol
Design
Cohort
Follow-up
3-year
Authors
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Supports U-shaped estradiol-mortality link in HFrEF men but should not change practice; leaves open causal role and need for prospective trials.
Is serum estradiol concentration associated with mortality in men with chronic heart failure and reduced LVEF?
In men with chronic heart failure and reduced LVEF, both low and high serum estradiol concentrations are associated with increased mortality, demonstrating a U-shaped relationship.
Ewa A. Jankowska (2009) studied this question.
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