Why the study?
Does onion extract prevent doxorubicin-induced apoptosis in aortic endothelial cells in rats?
Does onion extract prevent doxorubicin-induced apoptosis in aortic endothelial cells in rats?
Onion extract pretreatment reduces doxorubicin-induced apoptosis and oxidative stress in rat aortic endothelial cells.
May protect rat aortic endothelium from doxorubicin toxicity; hypothesis-generating and requires human validation before clinical consideration.
The aim of this study was to investigate the effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced apoptosis in aortic endothelial cells. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce aortic endothelial cell apoptosis, DOX (30 mg kg(-1) body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on antiapoptotic potential of ACE on DOX-induced apoptosis in aortic endothelial cells. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in aortic endothelial cells of the DOX-treated group with ACE therapy. DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels and increased levels of glutathione in comparison with the DOX-treated group. Data from our study show that prevention of endothelial cell apoptosis by ACE may contribute to the restoration of aortic endothelial dysfunction that is associated with DOX treatment.
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Alpsoy et al. (2011) studied this question.
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