Why the study?
Do endothelin-A receptor antagonists increase apoptosis in the aorta of DOCA-salt hypertensive rats?
Population
Deoxycorticosterone acetate (DOCA)-salt hypertensive rats and uninephrectomized controls
Comparison
Endothelin-A-selective receptor antagonists… vs Untreated DOCA-salt hypertensive rats
Design
Preclinical
Follow-up
4 weeks
Authors
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May support apoptosis as a mechanism of ET(A) antagonism in experimental hypertension; leaves open translation to human vascular remodeling.
Do endothelin-A receptor antagonists increase apoptosis in the aorta of DOCA-salt hypertensive rats?
Endothelin-A receptor antagonists may exert antihypertensive and anti-remodeling effects in DOCA-salt hypertensive rats partly by accentuating vascular apoptosis.
Sharifi et al. (1997) studied this question.
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