Why the study?
Do enalapril and amlodipine increase vascular smooth muscle apoptosis in spontaneously hypertensive rats?
Population
10-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) control rats
Comparison
Enalapril 10 mg/kg per day or amlodipine 20… vs Untreated SHR and WKY control rats
Design
Preclinical
Follow-up
12 weeks
Authors
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May mediate vascular remodeling by these agents in SHR models; hypothesis-generating and should not change practice.
Do enalapril and amlodipine increase vascular smooth muscle apoptosis in spontaneously hypertensive rats?
Antihypertensive agents like enalapril and amlodipine may inhibit vascular wall growth in hypertension partly by enhancing apoptosis.
Sharifi et al. (1998) studied this question.
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