Key result
Chronic administration of losartan in spontaneously hypertensive rats normalized left ventricular apoptosis, Bax expression, and the Bcl-2/Bax ratio independently of its hemodynamic effect.
Why the study?
Does losartan reduce apoptosis and Bax overexpression in the left ventricle of spontaneously hypertensive rats?
Does losartan reduce apoptosis and Bax overexpression in the left ventricle of spontaneously hypertensive rats?
Losartan prevents Bax overexpression and normalizes apoptosis in the left ventricle of spontaneously hypertensive rats, suggesting a direct role of AT1 receptors in cardiac apoptosis independent of hemodynamics.
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Preclinical data support AT1 blockade reducing LV apoptosis independently of hemodynamics; leaves open applicability to human hypertensive heart disease.
Fortuño et al. (1998) studied Spontaneous hypertension. Losartan vs. Untreated SHR and WKY rats was evaluated on Apoptosis density, Bax expression, and Bcl-2/Bax ratio. Chronic administration of losartan in spontaneously hypertensive rats normalized left ventricular apoptosis, Bax expression, and the Bcl-2/Bax ratio independently of its hemodynamic effect.
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