Key result
HLA-G expression is linked to ~73% fewer acute rejection episodes after heart transplantation.
Why the study?
The relationship between HLA-G expression after heart transplantation and the incidence of rejection was not well established.
Does HLA-G expression reduce the incidence of rejection in patients after heart transplantation?
Population
51 patients after heart transplantation
Comparison
HLA-G positive expression vs HLA-G negative expression
Design
Observational study with immunohistochemical and serum analysis
Follow-up
6 months
Authors
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HLA-G expression may identify lower rejection risk after heart transplant; leaves open whether monitoring or modulation improves outcomes in prospective trials.
Observational (n=51)
Does HLA-G expression reduce the incidence of rejection in patients after heart transplantation?
Absolute Event Rate: 1.2% vs 4.5%
p-value: p=<0.001
HLA-G expression after heart transplantation is associated with a significantly reduced incidence of both acute and chronic rejection.
Lila et al. (2002) conducted an observational in Heart transplantation (n=51). HLA-G expression vs. HLA-G-negative patients was evaluated on Number of episodes of acute rejection (p=<0.001). HLA-G expression after heart transplantation was associated with significantly fewer episodes of acute rejection (1.2 vs 4.5; P<0.001) and an absence of chronic rejection.
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