January 1, 2011Cellular Physiology and Biochemistry

Janus Kinase 3 is Expressed in Erythrocytes, Phosphorylated Upon Energy Depletion and Involved in the Regulation of Suicidal Erythrocyte Death

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Why the study?

Does JAK3 deficiency or inhibition prevent eryptosis in energy-depleted erythrocytes?

Population

Erythrocytes from JAK3-deficient mice (jak3(-/-)) and wild type mice (jak3(+/+))

Comparison

Glucose depletion and JAK3 inhibitors vs Wild type erythrocytes, or erythrocytes without…

Design

Preclinical

Follow-up

24h and 48h

Authors

SBShefalee K. BhavsarLeipzig University SGShuchen GuShanghai Ninth People's Hospital DBDiwakar BobbalaUniversité de Sherbrooke

Discussion

Member takes

Implication

JAK3 inhibition may blunt eryptosis in energy-depleted erythrocytes; leaves open therapeutic translation pending human studies.

Structured PICO

Does JAK3 deficiency or inhibition prevent eryptosis in energy-depleted erythrocytes?

Population

Erythrocytes from JAK3-deficient mice (jak3(-/-)) and wild type mice (jak3(+/+))

Intervention

Glucose depletion (24h and 48h) and JAK3 inhibitors (WHI-P131/JANEX-1 156μM and WHI-P154 11.2μM)

Comparator

Wild type erythrocytes, or erythrocytes without glucose depletion/inhibitors

Outcome

JAK3 expression and phosphorylation, phosphatidylserine exposure (annexin V binding), and cell volume (forward scatter)surrogate

JAK3 is expressed in erythrocytes and plays a novel role in triggering cell membrane scrambling during energy depletion-induced eryptosis.

Cite This Study

Bhavsar et al. (2011) studied this question.

synapsesocial.com/papers/6a83403c8dce46bed91322a0 https://doi.org/10.1159/000329956

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Janus Kinase 3 is Expressed in Erythrocytes, Phosphorylated Upon Energy Depletion and Involved in the Regulation of Suicidal Erythrocyte Death

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Janus Kinase 3 is Expressed in Erythrocytes, Phosphorylated Upon Energy Depletion and Involved in the Regulation of Suicidal Erythrocyte Death

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider