Why the study?
Does JANEX-1 reduce myocardial damage in a mouse model of ischemia/reperfusion injury?
Population
Young male mice subjected to 45 min of ischemia followed by varying periods of reperfusion, as well as in…
Comparison
JANEX-1 administered via intraperitoneal… vs Untreated or vehicle control (implied).
Design
Preclinical
Follow-up
varying periods of reperfusion
Authors
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Supports JAK3 inhibition in experimental myocardial I/R; leaves open translation to clinical cardioprotection.
Does JANEX-1 reduce myocardial damage in a mouse model of ischemia/reperfusion injury?
Pharmacological inhibition of JAK3 with JANEX-1 protects against myocardial ischemia and reperfusion injury in mice by reducing inflammation-mediated apoptotic damage.
Oh et al. (2013) studied this question.
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