Why the study?
Does TDZD-8 reduce myocardial infarct size in a rat model of acute ischemia-reperfusion injury?
Population
Anaesthetized Sprague-Dawley rats undergoing an open-chest procedure involving 30 min of myocardial ischemia…
Comparison
GSK-3beta inhibitor 4-benzyl-2-methyl-1, 2… vs Myocardial ischemia-reperfusion without TDZD-8
Design
Preclinical
Follow-up
6 hours
Authors
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TDZD-8 attenuates rat IR injury; hypothesis-generating for GSK-3β inhibition and requires clinical translation studies.
Does TDZD-8 reduce myocardial infarct size in a rat model of acute ischemia-reperfusion injury?
Inhibition of GSK-3beta with TDZD-8 at the time of reperfusion reduces myocardial infarct size, inflammation, and apoptosis in a rat model of ischemia-reperfusion injury.
Gao et al. (2008) studied this question.
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