Key result
Treatment with the apoptosis signal-regulating kinase-1 inhibitor GS-459679 at reperfusion significantly reduced infarct size by up to 60% (P<0.001) in a mouse model.
Why the study?
Does GS-459679 reduce infarct size in male CD1 mice undergoing transient coronary artery ligation and reperfusion?
Population
Male CD1 mice undergoing transient coronary artery ligation followed by reperfusion or sham surgery
Comparison
Selective small-molecule inhibitor of apoptosis… vs Vehicle
Design
Preclinical
Follow-up
7 days
Authors
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Hypothesis-generating for ASK1 inhibition in reperfusion injury; human trials needed before clinical consideration.
Does GS-459679 reduce infarct size in male CD1 mice undergoing transient coronary artery ligation and reperfusion?
Effect estimate: 31% reduction (10 mg/kg) and 60% reduction (30 mg/kg)
p-value: p=<0.001
Inhibition of apoptosis signal-regulating kinase-1 at the time of reperfusion significantly limits infarct size and preserves left ventricular function in a mouse model of acute myocardial infarction.
Toldo et al. (2012) studied Myocardial ischemia-reperfusion injury. GS-459679 vs. vehicle was evaluated on Infarct size (31% reduction (10 mg/kg) and 60% reduction (30 mg/kg), p=<0.001). Treatment with the apoptosis signal-regulating kinase-1 inhibitor GS-459679 at reperfusion significantly reduced infarct size by up to 60% (P<0.001) in a mouse model.
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