May 1, 2000British Journal of PharmacologyOpen Access

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

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Why the study?

Does caspase inhibition during early reperfusion reduce myocardial infarct size in a rat model of ischemia-reperfusion injury?

Structured PICO

Does caspase inhibition during early reperfusion reduce myocardial infarct size in a rat model of ischemia-reperfusion injury?

Population

Rat isolated hearts subjected to 35 min coronary occlusion and 120 min reperfusion

Intervention

Caspase inhibitors during early reperfusion (non-selective Z-VAD.fmk 0.1 microM, caspase-8 inhibitor Z-IETD.fmk 0.07 microM, caspase-9 inhibitor Z-LEHD.fmk 0.07 microM, or caspase-3 inhibitor Ac-DEVD.cmk 0.07 microM)

Comparator

Control

Outcome

Myocardial infarct size (infarct-risk ratio per cent)surrogate

Caspase inhibition during early reperfusion protects the myocardium against lethal reperfusion injury by limiting infarct size in a rat model.

Discussion

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Implication

Caspase inhibition may limit experimental reperfusion injury in rats; leaves open translation to clinical cardioprotection.

Cite This Study

Mocanu et al. (2000) studied this question.

synapsesocial.com/papers/6a7223a7febe604dd70a7486 https://doi.org/10.1038/sj.bjp.0703336

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