What does this research mean for the field?

The caspase inhibitor ZVAD-fmk reduces myocardial ischemia/reperfusion injury and improves hemodynamics in rats, an effect partially attributable to the attenuation of cardiomyocyte apoptosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 27, 1998Circulation

Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor

View Full Paper

Ask AI

Bookmark

Why the study?

Does ZVAD-fmk reduce myocardial infarct size and apoptosis in Sprague-Dawley rats subjected to ischemia/reperfusion injury?

Structured PICO

Does ZVAD-fmk reduce myocardial infarct size and apoptosis in Sprague-Dawley rats subjected to ischemia/reperfusion injury?

Population

Sprague-Dawley rats subjected to a 30-minute coronary occlusion followed by a 24-hour reperfusion (n=16)

Intervention

Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), total dose 3.3 mg/kg, administered intravenously every 6 hours starting at 30 minutes before coronary occlusion until 24 hours of reperfusion

Comparator

Inert vehicle (dimethylsulfoxide) administered intravenously

Outcome

Myocardial infarct size/ischemic area at risk and count of presumed apoptotic cardiomyocytes (TUNEL-positive cells) within the ischemic area at risk at 24 hourssurrogate

The caspase inhibitor ZVAD-fmk effectively reduces myocardial reperfusion injury and cardiomyocyte apoptosis in a rat model.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Reduces infarct size and apoptosis in rat I/R injury; hypothesis-generating for caspase inhibition in human reperfusion.

Cite This Study

Yaoita et al. (1998) studied this question.

synapsesocial.com/papers/6a1adfa49fa30811a0b93b5e https://doi.org/10.1161/01.cir.97.3.276

View Full Paper

Ask AI

Bookmark

Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor

Structured PICO

Discussion

Implication

Cite This Study

Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider