Key result
Peptidomimetic fluoromethyl ketone inhibitors of caspases at approximately 10 microM reduced myocyte injury most effectively when added before metabolic inhibition and continued throughout recovery.
Why the study?
Do caspase inhibitors reduce injury in isolated rabbit cardiomyocytes subjected to metabolic inhibition and recovery?
Population
Isolated adult rabbit cardiomyocytes subjected to metabolic inhibition (MI) and recovery
Design
Preclinical
Follow-up
4 or 24 hours
Authors
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Caspase inhibition may reduce myocyte injury with pre- and peri-insult timing; hypothesis-generating and requires in vivo validation before clinical consideration.
Do caspase inhibitors reduce injury in isolated rabbit cardiomyocytes subjected to metabolic inhibition and recovery?
Caspase inhibitors reduce injury in an in vitro model of myocardial ischemia and reperfusion, particularly when administered prior to the insult, supporting further in vivo investigation.
Li et al. (2001) studied Myocardial ischemia and reperfusion injury. Peptidomimetic fluoromethyl ketone inhibitors of caspases was evaluated on Myocyte injury. Peptidomimetic fluoromethyl ketone inhibitors of caspases at approximately 10 microM reduced myocyte injury most effectively when added before metabolic inhibition and continued throughout recovery.
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