March 1, 2001The Journal of ImmunologyOpen Access

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts

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Why the study?

Does inhibition of Jak3 with AG-490 prolong survival of rat heart allografts?

Population

Rat T cell line Nb2-11c and rat heart allograft model (heterotopically transplanted Lewis (RT1) heart…

Design

Preclinical

Authors

FBFariba BehbodUniversity of Kansas RERebecca Erwin-CohenNational Institutes of Health MWMouer WangUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Supports Jak3 inhibition in rodent allograft models; leaves open translation to clinical transplantation.

Structured PICO

Does inhibition of Jak3 with AG-490 prolong survival of rat heart allografts?

Population

Rat T cell line Nb2-11c and rat heart allograft model (heterotopically transplanted Lewis (RT1(l)) heart allografts in ACI (RT1(a)) recipients)

Intervention

Tyrphostin AG-490 (5-20 mg/kg i.v. for 7 days), alone or in combination with cyclosporin A or rapamycin

Outcome

Allograft survivalsurrogate

Inhibition of Jak3 with AG-490 prolongs heart allograft survival in rats and synergizes with cyclosporin A, suggesting a potential immunosuppressive strategy for transplantation.

Cite This Study

Behbod et al. (2001) studied this question.

synapsesocial.com/papers/6a83403c8dce46bed91322a8 https://doi.org/10.4049/jimmunol.166.6.3724

Topics

Heart transplantation

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Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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