What question did this study set out to answer?

To evaluate the association between various adiposity indicators and blood pressure, compare their predictive validity for hypertension, and determine risk-associated cut-off values in South Asian children.

February 1, 2019BMJ OpenOpen Access

Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study

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Why the study?

Given the South Asian phenotype of higher body fat at similar BMI relative to Caucasians, the validity of prominent adiposity indicators for estimating hypertension risk in South Asian children needed evaluation.

Are adiposity indicators associated with blood pressure and hypertension risk in South Asian children?

Population

762 South Asian children in two Canadian cities

Comparison

Different adiposity indicators (waist circumference, waist-to-height ratio, BMI, body fat percentage)

Design

Cross-sectional study

Authors

AFAdeleke O FowokanSimon Fraser University ZPZubin PunthakeeCentre for Advanced Study CWCharlotte WaddellSimon Fraser University

Discussion

Member takes

Implication

Adiposity may flag hypertension risk in South Asian children; leaves open ethnicity-specific cut-offs and prospective validation.

Key Points

To evaluate the association between various adiposity indicators and blood pressure, compare their predictive validity for hypertension, and determine risk-associated cut-off values in South Asian children.
Conducted a cross-sectional study enrolling 762 South Asian children across two Canadian cities (Hamilton and Surrey).
Measured waist circumference, waist-to-height ratio, BMI, body fat percentage via bioelectrical impedance analysis, and blood pressure via automated devices.
Used linear and Poisson regression alongside receiver operating characteristic (ROC) curves to evaluate diagnostic accuracy and identify sex-stratified cut-off points.
All adiposity indicators significantly associated with blood pressure z-scores and hypertension in unadjusted and adjusted models (p<0.01 for all).
ROC analyses yielded area under the curve (AUC) values between 0.74 and 0.80 across indicators for boys and girls.
Optimal cut-offs for elevated hypertension risk were identified at the 92nd (girls) and 82nd (boys) percentiles for BMI z-scores, and 29.8% (girls) and 23.5% (boys) for body fat percentage.

Structured PICO

Are adiposity indicators associated with blood pressure and hypertension risk in South Asian children?

Population

762 South Asian children recruited from two Canadian cities (Hamilton and Surrey)

Intervention

Adiposity indicators (waist circumference, waist to height ratio, BMI, body fat percentage)

Outcome

Association between adiposity indicators with blood pressure (BP) z-score and hypertension, and accuracy in estimating hypertension risksurrogate

South Asian children may be at adverse risk of hypertension at levels of adiposity considered normal, highlighting the need for population-specific risk cut-offs.

Cite This Study

Fowokan et al. (2019) studied this question.

synapsesocial.com/papers/6a83404e4245d6a429f2aff7 https://doi.org/10.1136/bmjopen-2018-024087

Topics

Hypertension management

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Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider