Why the study?
Do volatile anesthetics alter bradykinin-induced release of nitric oxide or L-citrulline in isolated guinea pig hearts?
Population
Isolated guinea pig hearts perfused at 55 mmHg with a crystalloid or erythrocyte perfusate at 37 degrees C
Comparison
Exposure to volatile anesthetics during infusion… vs Before and after exposure to anesthetics
Design
Preclinical
Authors
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Anesthetics appear neutral on coronary NO pathways in isolated hearts; leaves open translation to in vivo or clinical settings.
Do volatile anesthetics alter bradykinin-induced release of nitric oxide or L-citrulline in isolated guinea pig hearts?
Volatile anesthetics do not significantly affect nitric oxide production, release, or vasodilatory effects mediated by the eNOS cGMP pathway in isolated guinea pig hearts.
Fujita et al. (1998) studied this question.
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