February 1, 1993Journal of Cardiovascular Pharmacology

Marked Regional Heterogeneity in the Magnitude of EDRF/NO-Mediated Vascular Tone in Awake Rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does inhibition of EDRF/NO with NMMA alter systemic and regional hemodynamics in awake rats?

Population

Awake, indomethacin-treated rats

Comparison

Infusion of EDRF/NO synthesis inhibitor… vs Baseline (before infusion)

Design

Preclinical

Authors

EGEric P. GreenblattHospital of the University of Pennsylvania ALAlex L. LoebUniversity of Virginia DLDavid E. LongneckerUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Supports NO as key regulator of regional vascular resistance in rats; leaves open clinical relevance in humans.

Structured PICO

Does inhibition of EDRF/NO with NMMA alter systemic and regional hemodynamics in awake rats?

Population

Awake, indomethacin-treated rats

Intervention

Infusion of EDRF/NO synthesis inhibitor, NG-monomethyl-L-arginine (NMMA, 100 mg/kg), followed by reversal with L-arginine (300 mg/kg)

Comparator

Baseline (before infusion)

Outcome

Systemic and regional hemodynamic effects (cardiac output, systemic vascular resistance, regional blood flows, and regional vascular resistances in 12 tissues)surrogate

EDRF/NO is an important mediator of regional hemodynamic control in rats, with marked heterogeneity in basal EDRF/NO-dependent tone suggesting local regulation.

Cite This Study

Greenblatt et al. (1993) studied this question.

synapsesocial.com/papers/6a8bd0d3c12eaf65c8b21cba https://doi.org/10.1097/00005344-199302000-00008

View Full Paper

Ask AI

Bookmark

Marked Regional Heterogeneity in the Magnitude of EDRF/NO-Mediated Vascular Tone in Awake Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Marked Regional Heterogeneity in the Magnitude of EDRF/NO-Mediated Vascular Tone in Awake Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider