Key result
NO inhibition increases vascular resistance most in kidneys and least in the heart, modulated by TTX.
Population
Male Sprague-Dawley rats (n=13)
Comparison
NO synthase inhibitor, NG-nitro-l-arginine… vs l-NAME in the absence of TTX (n=5)
Design
Preclinical
Authors
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Organ-specific NO effects caution against uniform interventions; leaves open neural modulation of human vascular tone.
Basal NO production contributes heterogeneously to regional vascular resistance, with its effects modulated by baroreflex and nitroxidergic innervation depending on the organ.
Yamashita et al. (1996) studied this question. L-NAME in the presence or absence of tetrodotoxin (TTX) vs. Absence of TTX was evaluated on Changes in regional vascular resistance. Inhibition of NO production with L-NAME increased vascular resistance heterogeneously across organs, with the highest increase in the kidney and lowest in the heart, modulated by TTX.
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