July 1, 1998Journal of Cardiovascular Pharmacology

Monophosphoryl Lipid A Attenuates Myocardial Stunning in Dogs: Role of ATP-Sensitive Potassium Channels

View Full Paper

Ask AI

Bookmark

Why the study?

Does monophosphoryl lipid A improve regional segment shortening in a canine model of myocardial stunning?

Structured PICO

Does monophosphoryl lipid A improve regional segment shortening in a canine model of myocardial stunning?

Population

Barbital-anesthetized dogs subjected to myocardial stunning (five cycles of 5 min of left anterior descending coronary artery occlusion interspersed with 10 min of reperfusion, followed by 2 h of reperfusion)

Intervention

Single intravenous doses of monophosphoryl lipid A (MLA) 10-35 microg/kg given 24 h before ischemia, with or without glibenclamide (50 microg/kg, 15 min before ischemia)

Outcome

Regional segment shortening (%SS) determined by sonomicrometers implanted in the subendocardium of the ischemic region over a 2-h reperfusion periodsurrogate

Monophosphoryl lipid A attenuates myocardial stunning in a canine model via an ATP-sensitive potassium channel-dependent mechanism, mimicking the second window of ischemic preconditioning.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports K-ATP channel mediation of delayed preconditioning in canines; leaves open clinical translation to human myocardial stunning.

Cite This Study

Elliott et al. (1998) studied this question.

synapsesocial.com/papers/6a83405b6bd0b01a4e8cee89 https://doi.org/10.1097/00005344-199807000-00008

View Full Paper

Ask AI

Bookmark

Monophosphoryl Lipid A Attenuates Myocardial Stunning in Dogs: Role of ATP-Sensitive Potassium Channels

Structured PICO

Discussion

Implication

Cite This Study

Monophosphoryl Lipid A Attenuates Myocardial Stunning in Dogs: Role of ATP-Sensitive Potassium Channels

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider