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March 1, 2002Journal of Biological ChemistryOpen Access

Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway

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LXLei XuTongji UniversityDFDai FukumuraWestern University

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Xu et al. (2002) studied this question.

synapsesocial.com/papers/6a834212dd3eabac52f2b111https://doi.org/10.1074/jbc.m108347200
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of Vascular Endothelial Growth Factor and Its Receptors in the Anaplastic Progression of Astrocytoma, Oligodendroglioma, and Ependymoma1998 · 176 citations
  2. 2ERK activation upon hypoxia: involvement in HIF‐1 activation2000 · 377 citations