Sex associations and computed tomography coronary angiography-guided management in patients with stable chest pain
Why the study?
The relative benefits of CTCA-guided management in women and men with suspected angina due to coronary heart disease were uncertain.
Does standard care plus CTCA reduce the risk of CHD death or non-fatal myocardial infarction in patients with suspected angina compared to standard care alone?
Population
4146 patients referred for assessment of suspected angina from 12 UK cardiology clinics
Comparison
Standard care plus CTCA vs standard care alone, evaluated by sex
Design
Post hoc analysis of an open-label parallel-group multicentre randomized trial
Follow-up
Median of 4.8 years
Authors
Discussion
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Member takes
Implication
Supports CTCA-guided management in suspected angina regardless of sex; confirms similar prognostic benefit in women and men.
Structured PICO
Does standard care plus CTCA reduce the risk of CHD death or non-fatal myocardial infarction in patients with suspected angina compared to standard care alone?
P
Population
4,146 patients referred for assessment of suspected angina from 12 cardiology clinics across the UK
I
Intervention
Standard care plus computed tomography coronary angiography (CTCA)
C
Comparator
Standard care alone
O
Outcome
Risk of CHD death or non-fatal myocardial infarction at a median of 4.8 years follow-upcomposite
CTCA-guided management provides similar prognostic benefits for both women and men with suspected angina, despite women being more frequently reclassified as not having CHD.
Limitations
- post hoc analysis
Cite This Study
Mangion et al. (2019) studied this question.