Key result
Early CCTA reduces length of stay and admissions more in women than men versus standard ED evaluation.
Why the study?
Does early CCTA improve length of stay and hospital admission rates compared to standard ED evaluation in women versus men with acute chest pain?
Population
1000 patients (47% women) 40 to 74 years of age with symptoms suggestive of acute coronary syndrome
Comparison
Early cardiac computed tomographic angiography vs Standard emergency department (ED) evaluation
Design
RCT, Randomized
Authors
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Potential sex interaction in CCTA benefits for ED evaluation should not yet change practice; leaves open tailored strategies for validation.
RCT (n=1,000)
Yes
Does early CCTA improve length of stay and hospital admission rates compared to standard ED evaluation in women versus men with acute chest pain?
p-value: p=≤0.02
Early CCTA is an effective strategy for women presenting to the ED with acute chest pain, leading to greater reductions in length of stay and hospital admissions compared to men, likely due to lower CAD prevalence and severity.
Truong et al. (2013) conducted an RCT in acute chest pain (n=1,000). Early cardiac computed tomographic angiography (CCTA) vs. Standard emergency department (ED) evaluation was evaluated on Sex-based differences in length of stay, hospital admission rates, and cumulative radiation dose (p=≤0.02). Early CCTA resulted in a greater reduction in length of stay and hospital admissions compared to standard ED evaluation in women than in men (P for interaction ≤0.02).
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