Why the study?
Does the combination of elevated morning blood pressure surge and high serum uric acid increase the risk of cardiovascular events in hypertensive patients?
Does the combination of elevated morning blood pressure surge and high serum uric acid increase the risk of cardiovascular events in hypertensive patients?
The combination of elevated morning blood pressure surge and high serum uric acid is significantly associated with an increased risk of major cardiovascular events in hypertensive patients.
Combination of elevated MBPS and uric acid associated with higher CVE risk in hypertension; leaves open whether interaction warrants targeted intervention or risk stratification changes.
Early morning blood pressure surge (MBPS) is a risk factor for cardiovascular events (CVEs), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs. A total of 921 patients underwent 24-hour ambulatory blood pressure monitoring and were followed for a median of 40 months. During this period, 103 (11.2%) CVEs occurred. There was a significant relationship between increasing quartiles of serum uric acid level and increasing values of MBPS (P<.0001). Patients in the highest quartile stratified by elevated MBPS and serum uric acid level had a 3.55 odds of major CVE compared with patients in the lowest quartile. Serum uric acid is associated with MBPS and development of new CVEs.
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Turak et al. (2014) studied this question.
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