Key result
A 1-hour morning blood pressure surge >12 mm Hg was associated with decreased all-cause mortality (HR 0.61; 95% CI 0.47-0.79; P<0.001), particularly among nondipping subjects.
Why the study?
Does a morning blood pressure surge >12 mm Hg predict all-cause mortality in patients referred for ambulatory blood pressure monitoring?
Population
2,627 patients referred for ambulatory blood pressure monitoring with available values for at least 1-h…
Comparison
Morning blood pressure surge above median… vs Morning blood pressure surge below median
Design
Cohort
Follow-up
22,353 person-years of follow-up
Authors
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Higher morning surge should not alter ABPM risk assessment; leaves open whether the paradoxical mortality link in nondippers is causal or confounded.
Cohort (n=2,627)
Does a morning blood pressure surge >12 mm Hg predict all-cause mortality in patients referred for ambulatory blood pressure monitoring?
Hazard Ratio: 0.61 (95% CI 0.47–0.79)
p-value: p=< 0.001
In patients referred for ambulatory blood pressure monitoring, particularly nondippers, a higher morning blood pressure surge is paradoxically associated with decreased all-cause mortality.
Israel et al. (2011) conducted a cohort in Patients referred for ambulatory blood pressure monitoring (n=2,627). 1-h morning blood pressure surge >12 mm Hg vs. 1-h morning blood pressure surge ≤12 mm Hg was evaluated on All-cause mortality (HR 0.61, 95% CI 0.47-0.79, p=< 0.001). A 1-hour morning blood pressure surge >12 mm Hg was associated with decreased all-cause mortality (HR 0.61; 95% CI 0.47-0.79; P<0.001), particularly among nondipping subjects.
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