What question did this study set out to answer?

Identify retroviral antigenic determinants recognized by CD4+ helper T cells during tumor rejection in mice immune to Friend virus-induced FBL-3 tumors.

August 1, 1993Journal of VirologyOpen Access

Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells

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Authors

MIMichihiro IwashiroTakayanagi Dental Clinic TKTomohiro KondoOtsuka (Japan)TSTakeyuki ShimizuKōchi University

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Implication

Preclinical study identifies distinct retroviral envelope epitopes recognized by CD4+ T helper cells in immune mice, highlighting diverse targets for antitumor immunity.

Key Points

Identify retroviral antigenic determinants recognized by CD4+ helper T cells during tumor rejection in mice immune to Friend virus-induced FBL-3 tumors.
Generated four CD4+ helper T-cell clones by limiting dilution from mixed lymphocyte-tumor cultures of immune C57BL/6 and (BALB/c x C57BL/6)F1 mice.
Mapped antigenic epitopes using recombinant vaccinia viruses expressing Friend murine leukemia virus (F-MuLV) gag or env genes and defined targets using synthetic envelope peptides.
All four isolated CD4+ T-cell clones expressed unique alpha/beta T-cell receptor combinations and proliferated in response to FBL-3 tumor cells in an MHC class II-restricted manner.
Mapped two primary epitopes in the gp70 glycoprotein at residues 122–141 (cross-reactive with Moloney MuLV) and residues 462–479 (restricted to hybrid I-Eb/d molecules), along with a third non-cross-reactive N-terminal epitope.

Cite This Study

Iwashiro et al. (1993) studied this question.

synapsesocial.com/papers/6a8348d5cb426f3a69ae35cb https://doi.org/10.1128/jvi.67.8.4533-4542.1993

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Implication

Preclinical study identifies distinct retroviral envelope epitopes recognized by CD4+ T helper cells in immune mice, highlighting diverse targets for antitumor immunity.

Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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