Why the study?
The pathogenesis of Raynaud's phenomenon is not fully elucidated and definitive treatment remains an unmet need, necessitating a better understanding of underlying mechanisms to identify pharmacotherapeutic targets.
Design
Review
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May explain female predominance in Raynaud’s; hypothesis-generating for α2C-targeted therapies, pending clinical validation.
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Fardoun et al. (2025) studied this question.
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