August 1, 1992AJP Cell Physiology

ANP-(7-23) stimulates a DHP-sensitive Ca2+ conductance and reduces cellular cAMP via a cGMP-independent mechanism

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Population

Bovine adrenal glomerulosa cells

Comparison

Truncated ANP analogue, ANP-, at low and high… vs Control (no ANP-(7-23))

Design

Preclinical

Authors

CICarlos M. IsalesAugusta University JLJohn LewickiPoznan University of Medical Sciences JNJ. J. NeeUniversity of Virginia

Discussion

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Implication

ANP-(7-23) effects in bovine cells warrant clinical caution; leaves open cGMP-independent ANP-C signaling relevance in vivo.

Structured PICO

Population

Bovine adrenal glomerulosa cells

Intervention

Truncated ANP analogue, ANP-(7-23), at low (1 nM) and high (500 nM) concentrations

Comparator

Control (no ANP-(7-23))

Outcome

Cellular cGMP content, cytosolic calcium, cellular cAMP content, and aldosterone secretionsurrogate

Low-dose ANP-(7-23) selectively activates ANP-C(R2) receptors to decrease cellular cAMP and increase cytosolic calcium via a cGMP-independent mechanism in bovine adrenal glomerulosa cells.

Cite This Study

Isales et al. (1992) studied this question.

synapsesocial.com/papers/6a835120ec6f123fd6606f24 https://doi.org/10.1152/ajpcell.1992.263.2.c334

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ANP-(7-23) stimulates a DHP-sensitive Ca2+ conductance and reduces cellular cAMP via a cGMP-independent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ANP-(7-23) stimulates a DHP-sensitive Ca2+ conductance and reduces cellular cAMP via a cGMP-independent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider