Population
bovine adrenal glomerulosa cells stimulated by agonists that use the Ca2+-phosphoinositide messenger system
Design
Preclinical
Authors
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Supports distinct ANP-aldosterone signaling; hypothesis-generating for mechanism-targeted therapies pending human validation.
ANP inhibits aldosterone secretion without affecting the phosphoinositide-mediated calcium transient, suggesting its inhibitory action occurs via a different mechanism.
Apfeldorf et al. (1988) studied this question.
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