Why the study?
Does intravenous ANP reduce plasma aldosterone concentration in conscious sodium-depleted rats?
Population
Conscious unrestrained sodium-depleted rats
Design
Preclinical
Follow-up
120 min
Authors
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May suppress aldosterone in sodium depletion; leaves open translation to human HF or hypertension therapy.
Does intravenous ANP reduce plasma aldosterone concentration in conscious sodium-depleted rats?
Intravenous infusion of ANP significantly decreases plasma aldosterone concentration in conscious sodium-depleted rats, suggesting ANP modulates the effect of endogenous angiotensin II on aldosterone secretion.
Chartier et al. (1987) studied this question.
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