What question did this study set out to answer?

To determine whether rapid changes in intrathoracic pressure elicit reflex alterations in human skeletal muscle blood flow and evaluate the independence of muscle and skin vasomotor control.

May 1, 1958Circulation Research

Reflex Changes in Human Skeletal Muscle Blood Flow Associated with Intrathoracic Pressure Changes

View Full Paper

Ask AI

Bookmark

Why the study?

How do intrathoracic pressure changes affect human skeletal muscle blood flow?

Population

Humans

Design

Other

Authors

IRI. C. RoddieAstraZeneca (United Kingdom)JSJohn T. ShepherdCross-Cutting Cardiology RWR. F. WhelanQueen's University Belfast

Discussion

Member takes

Implication

May modulate limb perfusion during ventilation; leaves open vasomotor effects in cardiopulmonary disease.

Key Points

To determine whether rapid changes in intrathoracic pressure elicit reflex alterations in human skeletal muscle blood flow and evaluate the independence of muscle and skin vasomotor control.
Measured forearm blood flow during rapid alternating intrathoracic pressure changes induced by rapid breathing against partial airflow obstruction.
Assessed changes in forearm vascular response and vasoconstrictor tone following performance of the Valsalva maneuver.
Rapid alternating intrathoracic pressure changes caused a 3- to 4-fold increase in forearm blood flow.
Forearm blood flow decreased following the Valsalva maneuver via reflex changes in vasoconstrictor tone.
Observed reflex vasomotor adjustments were confined strictly to skeletal muscle vessels without involving cutaneous blood vessels.

Structured PICO

How do intrathoracic pressure changes affect human skeletal muscle blood flow?

Population

Humans

Intervention

Rapid alternating intrathoracic pressure changes (rapid breathing with partial obstruction) and Valsalva maneuver

Outcome

Forearm blood flowsurrogate

Intrathoracic pressure changes reflexly alter skeletal muscle blood flow via independent vasomotor centers.

Cite This Study

Roddie et al. (1958) studied this question.

synapsesocial.com/papers/6a835156c55df04bb862d47f https://doi.org/10.1161/01.res.6.3.232

View Full Paper

Ask AI

Bookmark

Reflex Changes in Human Skeletal Muscle Blood Flow Associated with Intrathoracic Pressure Changes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Reflex Changes in Human Skeletal Muscle Blood Flow Associated with Intrathoracic Pressure Changes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider