Why the study?
Does the addition of autologous platelet-rich plasma reverse the antiplatelet effects of ticagrelor ex vivo?
Population
20 healthy volunteers
Comparison
Addition of increasing amounts of autologous… vs Whole blood with ticagrelor without added PRP
Design
Preclinical
Authors
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May support platelet transfusion for ticagrelor reversal ex vivo; hypothesis-generating, requiring human trials before adoption.
Does the addition of autologous platelet-rich plasma reverse the antiplatelet effects of ticagrelor ex vivo?
Transfusion of platelet concentrates may be a viable strategy to reverse the antiplatelet effects of ticagrelor in bleeding patients or those requiring emergency surgery.
Hobl et al. (2013) studied this question.
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