Antagonizing P2Y12 Receptor Inhibitors: Current and Future Options

Patients on P2Y12 receptor inhibitors (clopidogrel, prasugrel, ticagrelor) requiring rapid reversal of platelet inhibition due to emergency situations such as active severe bleeding, urgent procedures with high bleeding risk, or major trauma.

Reversal strategies including platelet supplementation, serum albumin administration, hemadsorption, and the monoclonal antibody fragment PB2452.

Reversal of platelet inhibition (restoration of platelet function)surrogate