Why the study?
Because δ-opioid receptors are predominately expressed on group III spinal afferents, researchers investigated whether their activation in the dorsal horn attenuates pressor responses to stimuli activating these afferents in rats with patent or ligated femoral arteries.
Does intrathecal DPDPE attenuate the exercise pressor reflex in decerebrate rats?
Population
Decerebrate rats with patent or ligated femoral arteries
Comparison
Intrathecal DPDPE vs naltrindole or vehicle saline
Design
Animal experimental study
Authors
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Spinal δ-opioid agonism attenuates select pressor reflexes in rats; leaves open translation to human exercise or ischemic cardiovascular control.
Does intrathecal DPDPE attenuate the exercise pressor reflex in decerebrate rats?
Activation of spinal δ-opioid receptors attenuates reflexes evoked by group III afferents in both freely perfused and ligated rats.
Kim et al. (2019) studied this question.
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