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February 25, 2006AJP Heart and Circulatory Physiology

Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation

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Population

10 anesthetized cats

Comparison

Arterial injection of alpha,beta-Methylene ATP… vs Responses at different muscle temperatures

Design

Preclinical

Authors

ZGZhaohui GaoVKValerie KehoeJXJihong Xing

Discussion

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Overview

Attenuates P2X pressor reflexes at higher muscle temperatures in felines; hypothesis-generating for thermoregulatory effects on human muscle afferents.

Structured PICO

P
Population
10 anesthetized cats
I
Intervention
Arterial injection of alpha,beta-Methylene ATP (alpha,beta-MeATP) combined with muscle stretch or static muscle contraction at varying muscle temperatures (35, 37, and 39 degrees C)
C
Comparator
Responses at different muscle temperatures (35 and 37 degrees C vs 39 degrees C)
O
Outcome
Mean arterial pressure (MAP) responsesurrogate

Elevated muscle temperature attenuates P2X receptor-mediated reflex cardiovascular responses to muscle afferent activation in a feline model.

Cite This Study

Gao et al. (2006) studied this question.

synapsesocial.com/papers/6a83577bfd326746d0f2b352https://doi.org/10.1152/ajpheart.01303.2005
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