Differential Effects of Low- and High-Intensity Lower Body Negative Pressure on Noradrenaline and Adrenaline Kinetics in Humans
Why the study?
Does high-intensity lower body negative pressure compared to low-intensity alter catecholaminergic responses in healthy subjects?
Population
14 healthy subjects
Comparison
High-intensity lower body negative pressure… vs Low-intensity lower body negative pressure…
Design
Other
Authors
Discussion
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Implication
High-intensity LBNP may evoke generalized sympathoadrenal activation in healthy subjects; hypothesis-generating and should not yet change practice.
Structured PICO
Does high-intensity lower body negative pressure compared to low-intensity alter catecholaminergic responses in healthy subjects?
P
Population
14 healthy subjects
I
Intervention
High-intensity lower body negative pressure (-40 mmHg) during infusion of [3H]noradrenaline and [3H]adrenaline
C
Comparator
Low-intensity lower body negative pressure (-15 mmHg) during infusion of [3H]noradrenaline and [3H]adrenaline
O
Outcome
Forearm blood flow, noradrenaline spillover, total body noradrenaline and adrenaline spillover, and clearances of noradrenaline and adrenalinesurrogate
High-intensity lower body negative pressure evokes a generalized increase in sympathoneural activity and adrenomedullary secretion compared to low-intensity pressure, which selectively increases sympathoneural traffic to skeletal muscle.
Cite This Study
Jacobs et al. (1996) studied this question.