Why the study?
Are muscle interstitial lactate and ammonia mediators of the exercise pressor reflex (sympathetic activation) during exercise?
Population
17 humans, comprising 6 patients with McArdle's disease and 11 healthy, matched controls.
Comparison
Static arm flexor exercise at 30% of maximal… vs Healthy matched controls undergoing the same…
Design
Case-control
Authors
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Lactate unlikely primary mediator of exercise pressor reflex; challenges prevailing models and leaves open key metabolite identification.
Are muscle interstitial lactate and ammonia mediators of the exercise pressor reflex (sympathetic activation) during exercise?
Muscle acidification and changes in interstitial ammonia concentration are not the primary mediators of sympathetic activation (the exercise metaboreflex) during exercise.
Vissing et al. (2001) studied this question.
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