What question did this study set out to answer?

Determine whether exercise-induced muscle acidosis is required to trigger reflex muscle sympathetic nerve activation during static exercise.

April 15, 1998Journal of Clinical InvestigationOpen Access

Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.

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Authors

JVJohn VissingUniversity of Copenhagen SVSusanne VissingBritish Association of Dermatologists DMD. A. MacLeanCalgary Laboratory Services

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Implication

Physiological study reveals preserved sympathetic activation during exercise in metabolic myopathies, indicating that muscle acidosis is not required to stimulate the sympathetic nervous system.

Key Points

Determine whether exercise-induced muscle acidosis is required to trigger reflex muscle sympathetic nerve activation during static exercise.
Measured peroneal muscle sympathetic nerve activity (MSNA) using microneurography during static handgrip exercise (30% maximal voluntary contraction to exhaustion).
Enrolled 7 patients with myophosphorylase deficiency (McArdle's disease), 1 patient with phosphofructokinase deficiency, 1 patient with mitochondrial myopathy, and 5 healthy controls.
Monitored muscle pH dynamics before and during exercise using phosphorus-31 magnetic resonance spectroscopy.
MSNA increases over baseline were not blunted in McArdle's disease (17 ± 2 bpm, 124 ± 42%) or phosphofructokinase deficiency (65 bpm, 307%), and were not exaggerated in mitochondrial myopathy (24 bpm, 131%) compared to controls (17 ± 4 bpm, 115 ± 17%).
Muscle pH declined by 0.13 ± 0.02 U in controls and dropped by 0.51 U in mitochondrial myopathy, whereas muscle pH increased by 0.12 ± 0.05 U in McArdle's disease and by 0.01 U in phosphofructokinase deficiency.

Cite This Study

Vissing et al. (1998) studied this question.

synapsesocial.com/papers/6a83577ddd3eabac52f2b5c2 https://doi.org/10.1172/jci555

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Implication

Physiological study reveals preserved sympathetic activation during exercise in metabolic myopathies, indicating that muscle acidosis is not required to stimulate the sympathetic nervous system.

Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.

Discussion

Member takes

Implication

Key Points

Cite This Study

Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.

Discussion

Member takes

Implication

Key Points

Cite This Study

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