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October 1, 1988Journal of Clinical InvestigationOpen Access

Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans.

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Why the study?

Is the activation of muscle sympathetic nerve activity during exercise coupled to muscle pH or to concentrations of Pi and ADP in humans?

Population

Conscious humans

Design

Other

Authors

RVRonald G. VictorPennington Biomedical Research CenterLBL. A. BertocciUnited States Department of Veterans AffairsSPS L PryorThe University of Texas Southwestern Medical Center

Discussion

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Overview

Intracellular pH may mediate exercise MSNA activation; hypothesis-generating for sympathoexcitation mechanisms in disease.

Structured PICO

Is the activation of muscle sympathetic nerve activity during exercise coupled to muscle pH or to concentrations of Pi and ADP in humans?

P
Population
Conscious humans
I
Intervention
Static and rhythmic handgrip exercise with simultaneous 31P-NMR and muscle sympathetic nerve activity (MSNA) recording
O
Outcome
Correlation between muscle sympathetic nerve activity (MSNA) and intracellular muscle pH, inorganic phosphate (Pi), adenosine diphosphate (ADP), and phosphocreatine (PCr)surrogate

Activation of muscle sympathetic outflow during exercise in humans is coupled to the cellular accumulation of protons (decreased pH) in contracting muscle, rather than changes in Pi or ADP.

Cite This Study

Victor et al. (1988) studied this question.

synapsesocial.com/papers/6a73ec97cd7b40c8110dda24https://doi.org/10.1172/jci113730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential control of heart rate and sympathetic nerve activity during dynamic exercise. Insight from intraneural recordings in humans.1987 · 246 citations
  2. 2Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans.1985 · 750 citations
  3. 3Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: a gated 31P NMR study.1981 · 317 citations
  4. 4Does inadequate oxygen delivery trigger pressor response to muscle hypoperfusion during exercise?1987 · 83 citations
  5. 5Determination of Intracellular pH by 31P Magnetic Resonance1973 · 1,192 citations