Vascular Risk Status as a Predictor of Later-Life Depressive Symptoms: A Cohort Study
Why the study?
Do standard clinical vascular risk profiles predict new-onset depressive symptoms in older adults?
Population
5,318 participants from the Whitehall II study without depressive symptoms at baseline, mean age 54.8 years…
Design
Cohort
Follow-up
Baseline in 1991 with follow-up screenings in 1997, 2003…
Authors
Discussion
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Member takes
Implication
Vascular risk profiles may flag depression vulnerability before age 65; leaves open whether prevention alters incidence in observational data.
Structured PICO
Do standard clinical vascular risk profiles predict new-onset depressive symptoms in older adults?
P
Population
5,318 participants from the Whitehall II study without depressive symptoms at baseline, mean age 54.8 years, 31% women.
I
Intervention
Vascular risk assessment using Framingham Cardiovascular, Coronary Heart Disease, and Stroke Risk Scores
O
Outcome
New depressive symptoms identified by General Health Questionnaire caseness, Center for Epidemiologic Studies Depression Scale score ≥16, and use of antidepressant medicationpatient reported
Manifest vascular disease and high stroke risk scores predict the development of depressive symptoms in middle-aged adults, suggesting vascular prevention may also reduce later-life depression.
Cite This Study
Kivimäki et al. (2012) studied this question.