Key result
Atherosclerosis did not increase the risk of incident depressive symptoms (HR 0.93; 95% CI 0.83-1.05) or syndromes (HR 0.97; 95% CI 0.81-1.16) in older adults over an average of 6 years.
Why the study?
Does atherosclerosis increase the risk of developing depression in older adults?
Population
3564 older adults who initially did not have depression or dementia, from the Rotterdam study.
Design
Cohort
Follow-up
average of 6 years
Authors
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Atherosclerosis was not associated with incident depression in older adults; leaves open the vascular depression hypothesis for prospective confirmation.
Cohort (n=3,564)
Does atherosclerosis increase the risk of developing depression in older adults?
Hazard Ratio: 0.93 (95% CI 0.83–1.05)
Atherosclerosis does not appear to increase the risk of incident depression in older adults, challenging the vascular depression hypothesis.
Newson et al. (2010) conducted a cohort in Incident depression (n=3,564). Atherosclerosis was evaluated on Incident depressive symptoms (HR 0.93, 95% CI 0.83-1.05). Atherosclerosis did not increase the risk of incident depressive symptoms (HR 0.93; 95% CI 0.83-1.05) or syndromes (HR 0.97; 95% CI 0.81-1.16) in older adults over an average of 6 years.
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