Why the study?
Is type 2 diabetes mellitus associated with altered mitochondrial oxygen consumption in PBMCs and does it correlate with vascular dysfunction compared to non-diabetic controls?
Population
54 subjects, comprising 26 patients with type 2 diabetes mellitus and 28 non-diabetic controls.
Comparison
Type 2 diabetes mellitus (observational exposure) vs Non-diabetic controls
Design
Cross-sectional
Authors
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T2DM was associated with higher PBMC mitochondrial oxygen consumption correlating with vascular dysfunction; hypothesis-generating and leaves open causality.
Is type 2 diabetes mellitus associated with altered mitochondrial oxygen consumption in PBMCs and does it correlate with vascular dysfunction compared to non-diabetic controls?
Type 2 diabetes mellitus is associated with higher mitochondrial oxygen consumption in PBMCs, which correlates with impaired vascular smooth muscle cell function (nitroglycerin-mediated dilation).
Hartman et al. (2014) studied this question.
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