Why the study?
Does streptozotocin-induced diabetes alter the contractile and histochemical properties of rat muscles?
Population
Mature rats
Comparison
Streptozotocin-induced diabetes for 3 months vs Age- and weight-matched controls
Design
Preclinical
Follow-up
3 months
Authors
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Rat muscle changes in diabetes require human validation before clinical use; leaves open translational relevance to diabetic myopathy.
Does streptozotocin-induced diabetes alter the contractile and histochemical properties of rat muscles?
Long-term streptozotocin-induced diabetes in rats causes profound wasting of fast muscles and slowing of slow muscles with impaired oxidative capacity.
Cotter et al. (1989) studied this question.
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