Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-γ activation

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Population

Rats with innervated and surgically denervated brown adipose tissue (BAT) pads

Comparison

Rosiglitazone and/or cold exposure vs Untreated rats and/or innervated vs denervated…

Design

Preclinical

Follow-up

7 days

Authors

Discussion

Animal findings on rosiglitazone and BAT UCP1 should not change practice; leaves open neural dependence in human metabolic research.

Population

Rats with innervated and surgically denervated brown adipose tissue (BAT) pads

Intervention

Rosiglitazone (15 mg/kg/day for 7 days) and/or cold exposure (5 degrees C, 24 h)

Comparator

Untreated rats and/or innervated vs denervated BAT pads

Outcome

BAT weight, triacylglycerol (TAG) and DNA content, mitochondrial mass, and gene expression (including UCP1)surrogate

Maximal UCP1 expression induced by PPAR-gamma activation in vivo depends on the presence of basal BAT adrenergic tone.

Festuccia et al. (2010) studied this question.

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