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March 1, 1972European Journal of Endocrinology

Plasma Cortisol, Corticosterone and Non-Protein-Bound Cortisol in Extracorporeal Circulation

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Why the study?

How does extracorporeal circulation affect plasma cortisol, corticosterone, and non-protein-bound cortisol levels compared to major surgery without perfusion?

Population

14 patients undergoing extracorporeal circulation, and a comparison group of major surgery without perfusion

Comparison

Extracorporeal circulation during surgery vs Major surgery without perfusion

Design

Cohort

Follow-up

During and immediately after perfusion

Authors

TUT UozumiHiroshima UniversityHMHisao ManabeTottori UniversityYKY KawashimaTottori University

Discussion

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Implication

Associated with higher free cortisol during perfusion; leaves open whether this alters perioperative management versus non-perfusion surgery.

Structured PICO

How does extracorporeal circulation affect plasma cortisol, corticosterone, and non-protein-bound cortisol levels compared to major surgery without perfusion?

P
Population
14 patients undergoing extracorporeal circulation, and a comparison group of major surgery without perfusion (200 plasma samples)
I
Intervention
Extracorporeal circulation during surgery
C
Comparator
Major surgery without perfusion
O
Outcome
Levels of plasma cortisol, corticosterone, and non-protein-bound cortisolsurrogate

Extracorporeal circulation decreases cortisol binding capacity, increasing biologically active non-protein-bound cortisol despite a drop in total cortisol.

Cite This Study

Uozumi et al. (1972) studied this question.

synapsesocial.com/papers/6a836205ec11ec487997e047https://doi.org/10.1530/acta.0.0690517
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EFFECTS OF SURGERY ON PLASMA LEVELS OF CORTISOL, CORTICOSTERONE AND NON-PROTEIN-BOUND-CORTISOL1970 · 42 citations
  2. 2CORTISOL BINDING CAPACITY IN PLASMA DURING ANAESTHESIA AND SURGERY1974 · 59 citations
  3. 3DYNAMICS OF BLOOD CORTISOL LEVELS IN ABDOMINAL AORTIC SURGERY IN CONDITIONS OF MULTICOMPONENT WELL-BALANCED ANESTHESIA2018
  4. 4Circadian Rhythm of Cortisol is Altered in Postsurgical Patients*1981 · 63 citations
  5. 5Plasma levels of glucose, insulin and cortisol in children undergoing cardiac surgery: effects of pulsatile and nonpulsatile perfusion1989 · 3 citations