Key result
Pulsatile perfusion during extracorporeal circulation did not significantly alter glucose, insulin, and cortisol responses compared to nonpulsatile perfusion in children undergoing cardiac surgery.
Why the study?
Does pulsatile perfusion alter the glucose, insulin, and cortisol response compared to nonpulsatile perfusion in children undergoing intracardiac repair of congenital heart defects?
Population
12 children undergoing intracardiac repair of congenital heart defects
Comparison
Pulsatile perfusion delivered by a modified… vs Nonpulsatile perfusion during extracorporeal…
Design
Cohort
Follow-up
24 hours
Authors
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No metabolic benefit seen with pulsatile perfusion; leaves open whether RCTs would detect differences in stress responses or outcomes.
Observational (n=12)
Does pulsatile perfusion alter the glucose, insulin, and cortisol response compared to nonpulsatile perfusion in children undergoing intracardiac repair of congenital heart defects?
Pulsatile perfusion during extracorporeal circulation does not significantly alter the metabolic stress response (glucose, insulin, cortisol) in children undergoing congenital heart surgery compared to nonpulsatile perfusion.
Vigneswaran et al. (1989) conducted an observational in Congenital heart defects (n=12). Pulsatile perfusion vs. Nonpulsatile perfusion was evaluated on Plasma glucose, insulin and cortisol levels. Pulsatile perfusion during extracorporeal circulation did not significantly alter glucose, insulin, and cortisol responses compared to nonpulsatile perfusion in children undergoing cardiac surgery.
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