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November 1, 2010Artificial OrgansOpen Access

Evaluation of Perfusion Modes on Vital Organ Recovery and Thyroid Hormone Homeostasis in Pediatric Patients Undergoing Cardiopulmonary Bypass

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Why the study?

Does pulsatile perfusion improve vital organ recovery and thyroid hormone homeostasis compared to nonpulsatile perfusion in pediatric patients undergoing cardiopulmonary bypass?

Population

289 consecutive pediatric patients undergoing open heart surgery for repair of congenital heart disease

Comparison

Pulsatile perfusion during cardiopulmonary bypass vs Nonpulsatile perfusion during cardiopulmonary…

Design

RCT, randomly assigned

Follow-up

early postoperative period (up to 72 hours)

Authors

AAAtıf AkçevinKoç UniversityTATijen Alkan‐BozkayaYeditepe University HospitalFQFeng QiuNingbo University

Discussion

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Implication

Pulsatile perfusion may reduce support needs and stay in pediatric CPB; extends RCT evidence for organ recovery and thyroid preservation.

Structured PICO

Does pulsatile perfusion improve vital organ recovery and thyroid hormone homeostasis compared to nonpulsatile perfusion in pediatric patients undergoing cardiopulmonary bypass?

P
Population
289 consecutive pediatric patients undergoing open heart surgery for repair of congenital heart disease
I
Intervention
Pulsatile perfusion during cardiopulmonary bypass
C
Comparator
Nonpulsatile perfusion during cardiopulmonary bypass
O
Outcome
Vital organ recovery (including total drainage, mean urine output in ICU, intubation time, duration of ICU and hospital stay, need for inotropic support, enzyme levels, CRP, lactate, albumin, blood count, creatinine) and thyroid hormone homeostasis (TSH, FT3, FT4)surrogate

Pulsatile perfusion during cardiopulmonary bypass in pediatric patients improves early clinical outcomes and better preserves thyroid hormone homeostasis compared to nonpulsatile perfusion.

Cite This Study

Akçevin et al. (2010) studied this question.

synapsesocial.com/papers/6a901d1baa54517f3533cdeahttps://doi.org/10.1111/j.1525-1594.2010.01159.x

Topics

Congenital heart disease adults
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Pulsatile CPB on Interleukin‐8 and Endothelin‐1 Levels2005 · 76 citations
  2. 2Thyroid Hormone and Cardiac Surgery2002 · 65 citations
  3. 3A Performance Evaluation of Eight Geometrically Different 10 Fr Pediatric Arterial Cannulae Under Pulsatile and Nonpulsatile Perfusion Conditions in an Infant Cardiopulmonary Bypass Model2008 · 39 citations
  4. 4Hemodynamic Energy Delivery of the Pulsatile Flow in a Simulated Pediatric Extracorporeal Circuit2008 · 15 citations
  5. 5The Impact of Pump Settings on the Quality of Pulsatility2008 · 21 citations