Key result
Cardiopulmonary bypass led to a significant transient depression of total thyroxin, total triiodothyronine, and free triiodothyronine up to 24 hours postoperatively (P<0.05).
Why the study?
Does cardiopulmonary bypass alter thyroid hormone levels in patients?
Observational (n=20)
Does cardiopulmonary bypass alter thyroid hormone levels in patients?
Answers are grounded in this paper and cite their sources.
Cardiopulmonary bypass causes a transient depression in thyroid hormone metabolism, characterized by low levels of circulating TT4, TT3, and fT3.
The haemodynamic effects of thyroid hormones are well known and include those on heart rate, contractility and myocardial oxygen consumption. Cardiopulmonary bypass produces various alterations in endocrine homoeostasis and may exert important haemodynamic effects postoperatively. The purpose of this prospective study was to determine the relation of cardiopulmonary bypass to changes in thyroid function. Blood samples were obtained from 20 patients preoperatively, at specific times before, during and after cardiopulmonary bypass. Total thyroxin (TT4), total triiodothyronine (TT3), free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), thyroid-binding globulin (TBG) and albumin were measured by radioimmunoassay and competitive immunoassay. Values of TT4, TT3 and fT3 were significantly depressed up to 24 h after cardiopulmonary bypass ( P < 0.05). TSH and fT4 levels remained within normal ranges at all sampling times. It is increasingly evident that cardiopulmonary bypass affects thyroid hormone metabolism, leading to a transient depression characterized by low levels of circulating TT4, TT3 and fT3.
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Keçeligil et al. (1996) conducted an observational in Patients undergoing cardiopulmonary bypass (n=20). Cardiopulmonary bypass vs. Preoperative baseline was evaluated on Changes in thyroid hormone levels (TT4, TT3, fT4, fT3, TSH, TBG, and albumin) (p=<0.05). Cardiopulmonary bypass led to a significant transient depression of total thyroxin, total triiodothyronine, and free triiodothyronine up to 24 hours postoperatively (P<0.05).
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