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March 6, 1996JAMA

Cardiovascular Effects of Intravenous Triiodothyronine in Patients Undergoing Coronary Artery Bypass Graft Surgery

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Why the study?

Does intravenous triiodothyronine improve hemodynamic variables and decrease inotropic drug requirements in patients undergoing coronary artery bypass graft surgery?

Population

211 patients undergoing coronary artery bypass graft surgery at high risk for requiring inotropic drug support

Comparison

Intravenous infusion of triiodothyronine… vs Intravenous dopamine or placebo

Design

RCT, randomized, double-blind, placebo-controlled

Follow-up

perioperative

Authors

EBElliott Bennett‐GuerreroApple (Israel)

Discussion

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Implication

Does not support intravenous triiodothyronine for hemodynamic support in CABG; reinforces avoidance of routine use and directs research elsewhere.

Structured PICO

Does intravenous triiodothyronine improve hemodynamic variables and decrease inotropic drug requirements in patients undergoing coronary artery bypass graft surgery?

P
Population
211 patients undergoing coronary artery bypass graft surgery at high risk for requiring inotropic drug support
I
Intervention
Intravenous infusion of triiodothyronine (T3) (0.8 μg/kg followed by 0.12 μg·kg-1·h-1 for 6 hours) administered at the release of aortic cross-clamp
C
Comparator
Intravenous dopamine (5 μg·kg-1·min-1 for 6 hours) or placebo
O
Outcome
Perioperative hemodynamic variables, inotropic support requirements, and serum T3 concentrationssurrogate

Routine use of intravenous triiodothyronine as an inotropic agent in patients undergoing coronary artery bypass graft surgery is not recommended as it does not significantly improve hemodynamics or reduce inotropic requirements.

Cite This Study

Elliott Bennett‐Guerrero (1996) studied this question.

synapsesocial.com/papers/6a908c5db71d06dae589ef63https://doi.org/10.1001/jama.1996.03530330031025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open heart surgery1989 · 109 citations
  2. 2Triiodothyronine therapy in open-heart surgery: from hope to disappointment1993 · 37 citations
  3. 3Effects of Acute Triiodothyronine Treatment in Patients with Anterior Myocardial Infarction Undergoing Primary Angioplasty: Evidence from a Pilot Randomized Clinical Trial (ThyRepair Study)2022 · 25 citations
  4. 4Thyronin Treatment in Adult and Pediatric Heart Surgery: Clinical Experience and Review of the Literature2002 · 30 citations
  5. 5Acute severe postischemic myocardial depression reversed by triiodothyronine1992 · 38 citations