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May 1, 1993European Heart Journal

Triiodothyronine therapy in open-heart surgery: from hope to disappointment

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Why the study?

Does intravenous triiodothyronine (T3) improve haemodynamic recovery and beta-adrenergic responsiveness in patients undergoing cardiac surgery with cardiopulmonary bypass?

Population

20 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)

Comparison

Triiodothyronine given intravenously at the time… vs Placebo solution given intravenously at the time…

Design

RCT, randomized, double-blind

Follow-up

up to 20 hours post-aortic unclamping

Authors

ETEmmanuel TeígerInterventional CardiologyPMPhilippe MenaschéInsermPMP. MansierOregon National Primate Research Center

Discussion

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Implication

Does not support routine perioperative T3 in cardiac surgery with bypass; confirms neutral effects on haemodynamics and beta-adrenoceptors.

Structured PICO

Does intravenous triiodothyronine (T3) improve haemodynamic recovery and beta-adrenergic responsiveness in patients undergoing cardiac surgery with cardiopulmonary bypass?

P
Population
20 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)
I
Intervention
Triiodothyronine (T3) given intravenously at the time of aortic unclamping and 4, 8, 12 and 20 h thereafter
C
Comparator
Placebo solution given intravenously at the time of aortic unclamping and 4, 8, 12 and 20 h thereafter
O
Outcome
Thyroid hormone levels, standard haemodynamic parameters, and density of lymphocyte beta-adrenoceptorssurrogate

Routine peri-operative administration of intravenous T3 does not improve haemodynamics or beta-adrenergic responsiveness in patients undergoing open-heart surgery with cardiopulmonary bypass.

Cite This Study

Teíger et al. (1993) studied this question.

synapsesocial.com/papers/6a908c5db71d06dae589ef64https://doi.org/10.1093/eurheartj/14.5.629

Topics

Valvular heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open heart surgery1989 · 109 citations
  2. 2Cardiovascular Effects of Intravenous Triiodothyronine in Patients Undergoing Coronary Artery Bypass Graft Surgery1996 · 140 citations
  3. 3Thyroid Hormone Alterations during and after Cardiopulmonary Bypass1996 · 2 citations
  4. 4Effects of Acute Triiodothyronine Treatment in Patients with Anterior Myocardial Infarction Undergoing Primary Angioplasty: Evidence from a Pilot Randomized Clinical Trial (ThyRepair Study)2022 · 25 citations
  5. 5Evaluation of Perfusion Modes on Vital Organ Recovery and Thyroid Hormone Homeostasis in Pediatric Patients Undergoing Cardiopulmonary Bypass2010 · 29 citations